Enhanced Recovery of Gut-Associated Lymphoid Tissue by Infusion of Buffy Coat Cells and Gut Leukocytes in the Murine Syngeneic Bone Marrow Transplantation
نویسندگان
چکیده
Ways of accelerating recovery of the mucous membrane immune system in lethally irradiated mice following syngeneic bone marrow transplantation were studied over a 35-day period by quantification of jejunal intraepithelial lymphocytes (lEis) and lamina propria plasma cells. Recovery after a low bone marrow dose allowing 1 00% animal survival (IBM) was compared with a high (five times minimal) dose (HBM). or a minimal dose augmented with equal numbers of buffy coat cells (IBM + BC) or small gut mucosal lymphocytes (IBM + GI). The maximal decline and subsequent peak repopulation of lEls were: IBM, days 7 through 14, peaking suboptimally by day 28; HBM. day 14,
منابع مشابه
Enhanced recovery of gut-associated lymphoid tissue by infusion of buffy coat cells and gut leukocytes in the murine syngeneic bone marrow transplantation model.
Ways of accelerating recovery of the mucous membrane immune system in lethally irradiated mice following syngeneic bone marrow transplantation were studied over a 35-day period by quantification of jejunal intraepithelial lymphocytes (IELs) and lamina propria plasma cells. Recovery after a low bone marrow dose allowing 100% animal survival (LBM) was compared with a high (five times minimal) dos...
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