Enhanced Recovery of Gut-Associated Lymphoid Tissue by Infusion of Buffy Coat Cells and Gut Leukocytes in the Murine Syngeneic Bone Marrow Transplantation

نویسندگان

  • George S. Leventon
  • Robert A. White
چکیده

Ways of accelerating recovery of the mucous membrane immune system in lethally irradiated mice following syngeneic bone marrow transplantation were studied over a 35-day period by quantification of jejunal intraepithelial lymphocytes (lEis) and lamina propria plasma cells. Recovery after a low bone marrow dose allowing 1 00% animal survival (IBM) was compared with a high (five times minimal) dose (HBM). or a minimal dose augmented with equal numbers of buffy coat cells (IBM + BC) or small gut mucosal lymphocytes (IBM + GI). The maximal decline and subsequent peak repopulation of lEls were: IBM, days 7 through 14, peaking suboptimally by day 28; HBM. day 14,

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تاریخ انتشار 2005